Research
OVERVIEW

Our laboratory is using cellular, molecular, mouse genetics, bioengineering, and bioinformatics tools to understand how mechanical forces generated by the flow of blood act on endothelial cells to activate signaling pathways critical for flow-mediated vasoprotection in the context of human cardiovascular disease, and for cellular specification during developmental processes.

The ultimate objectives of our research program are twofold: to generate a molecular description of flow-mediated endothelial mechanotransduction in specific biological processes, in order to provide a framework for understanding how genes and hemodynamic environments dictate cell fate decisions and functional phenotypes; and to probe these molecular maps to improve diagnosis and treatment of human disease.


Projects

BIOMECHANICAL CONTROL OF ENDOTHELIAL VASOPROTECTION BIOMECHANICAL CONTROL OF EMBRYONIC DEVELOPMENT